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Dosages of less than 5 mg prednisolone per day are not significant and no steroid cover is requiredfor patients on a daily tablet regimen. In rare cases, a drug may not be effective because the patient has certain symptoms of anaphylaxis; in such cases, the doctor may prescribe prednisolone for the treatment or management of these symptoms. In some cases, a patient on a daily tablet regime can avoid the need for steroid use, especially if the steroid regimen is shorter and shorter in duration. The patient should be evaluated for additional underlying medical conditions, such as diabetes mellitus. There have been no reported cases of allergic skin reactions from prednisolone and, therefore, the risk for reaction to anaphylaxis from this agent is very small. Carcinogens are a possible route of exposure to prednisolone. It is important for patients on a daily daily steroid regimen to take prednisolone with the rest of their prescribed steroids to prevent any residual corticosteroid exposure. Patients should be monitored for the development of anaphylactic reactions, and emergency treatment for anaphylactic reactions may be necessary. If the patient develops such anaphylactic reaction, a steroid may not be effective in the treatment or management of the patient's underlying medical condition. If treatment is given, it should be done promptly and in a doctor's office rather than in a pharmacy. Pregnancy Very little information is available about the pharmacologic effects of prednisolone. Studies in healthy infants have demonstrated very low serum concentrations of prednisolone following neonatal administration to infants and suggested that this substance may not become active in infants exposed to glucocorticoids. However, it is important for pregnant women to discuss with their prescriber the possibility of taking prednisolone before delivery and the risk for prednisolone use along the route of pregnancy. The benefits of such use and treatment are unknown. Pediatric Use Pregnancy Pregnancy Category D Precautions Infection Pregnancy is not known to be associated with increased risk of infection with sulfonamides. Infection with sulfonamides occurs with frequent dosing regimens of sulfonamides. The possibility of infection should be considered when making dose adjustments to prednisolone formulations. Fluid retention Pregnancy should not be used as a consideration for the use of sulfonamides in pregnancy. General Pregnancy and lactation The effectiveness of sulfonamides Related Article: